10August 2022

Polyglactin 910: Synthetic Absorbable Suture

A copolymer consisting of 90% glycolide and 10% L-lactide makes up the synthetic, absorbable, sterile surgical suture known as Polyglactin 910. The suture is available in Undyed and is dyed with FDA-approved dyes D and C violet. In-house needle manufacture gives you the best needles with the maximum sharpness, resulting in smooth tissue contact when suturing. According to the United States Pharmacopeia for Synthetic Absorbable Suture, Polyglactin 910 satisfies all the standards.

It is a twisted, multifilament, absorbable suture with a synthetic coating that tends to make the thread less irritating when it passes through tissues and has a more prolonged absorption time and improved tensile strength. The Polyglactin 910 suture undergoes chemical hydrolysis degradation before being ingested and metabolized by the body, and the suture loses mass after absorption and is wholly reabsorbed in 90 days. Because of its improved tensile strength, predictable absorption, and lack of tissue reactivity, ORYL910 – Polyglactin910 Suture is a far preferable option to catgut sutures.

Properties of Polyglactin 910 are: –

● High tensile strength

● Composition: Poly(glycolide/L-Lactide) i.e., Polyglactin 910

● Structure: Multifilament, Braided

● Colour: Dyed

● Sizes: Dyed: USP 8/0 – USP 2

● Suture Length (cm): 35- 180

● Needle Dimensions and Profiles: A variety ranging from 9 mm to 60 mm

● dependable knot security

● smooth passage through tissue that causes no damage.

● General surgery

● gynecological

● gastrointestinal tract surgery, 

● Ocular procedures all require polyglactin sutures.

● Cardiovascular and neurological treatments do not use it.

Performance of Polyglactin 910 Sutures

Due to (limited) initial inflammatory tissue reaction, Polyglactin 910 suture causes the formation of fibrous connective tissue. The tissues steadily deteriorate in tensile strength before being consumed by the hydrolytic process. The copolymer breaks down into glycolic and lactic acids during hydrolysis, which are subsequently absorbed and metabolized by the body. Significant tensile strength, with 75% of the original remaining up to the first 14 days, 40%–50% to the first 21 days (for sizes 6-0 and bigger), (7-0 and smaller), and 24% to the first 28 days (6-0 and larger). A second loss occurs four to five weeks after implantation. Suture complete absorption typically takes 56 to 75 days.

Sterility:

By using ethylene oxide, Polyglactin 910 sutures are sterilized (EtO). Re-sterilizing could cause the product to degrade and stop working as it should. If the package is damaged or opened, do not use it. Throw away any unsealed, unused sutures.

Contradictions:

Since suture is absorbable, it is not advised when an extended approximation of tissues under stress is needed.

Storage:

Sutures made of Polypropylene should be stored between 15 and 30 OC, away from dampness and intense heat. Use only until the expiration date.

Conclusion

In cutaneous surgery, polyglactin 910 is frequently utilized. Without a statistically significant difference in scar quality, it has been directly compared with polydioxanone for usage in rhytidectomy reconstruction and poly trimethylene carbonate for Mohs reconstruction. Compared to incisions sutured with polydioxanone or poliglecaprone 25, those using Polyglactin 910 have a higher incidence of hypertrophic scars, according to other studies. Vicryl-Rapide (Ethicon), a version of Polyglactin 910 that dissolves more quickly, was created to mimic the functionality of surgical gut sutures. Vicryl-Rapide has a higher rate of tissue absorption than standard suture Polyglactin 910 since it is made of a polymer substance with a lower molecular weight.

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